A novel approach to simultaneously scan genes at fragile sites
نویسندگان
چکیده
منابع مشابه
Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites.
Fragile sites are specific regions of chromosomes that are prone to breakage. In cells cultured under conditions that induce fragile site expression, high levels of inter- and intrachromosomal recombination have been observed involving chromosomal bands containing fragile sites. To determine whether expression of specific fragile sites would facilitate preferential integration of exogenous DNA ...
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Common Chromosomal Fragile Sites (CFSs) are specific genomic regions prone to form breaks on metaphase chromosomes in response to replication stress. Moreover, CFSs are mutational hotspots in cancer genomes, showing that the mutational mechanisms that operate at CFSs are highly active in cancer cells. Orthologs of human CFSs are found in a number of other mammals, but the extent of CFS conserva...
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A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs). Recently, we have reported that miR-15a and miR-16a, located at 13q14, are frequently deleted and/or down-regulated in patients with B cell chronic lymphocytic leukemia, a disorder characterized by increased survival. To further investigate the possible involvement of miRs in human cancers on a genome-wide basis,...
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A new chemical compound is developed at Petroleum University of Technology to enhance the recovery of the free imbibition process and simultaneously hinder asphaltene precipitation. The compound is tested on heavy oil samples from Marun oil field, Bangestan reservoir. The effects of the chemical compound on viscosity, hydrocarbon composition, and average molecular weight of the heavy oil are in...
متن کاملCommon fragile sites.
Aphidicolin-induced common fragile sites are site-specific gaps or breaks seen on metaphase chromosomes after partial inhibition of DNA synthesis. These fragile sites were first recognized during the early studies of the fragile X syndrome and are induced by the same conditions of folate or thymidylate stress used to induce the fragile X site. Common fragile sites are normally stable in culture...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2006
ISSN: 1471-2407
DOI: 10.1186/1471-2407-6-205